应用噻替派和丝裂霉素 C 溶液浸泡离体人类膀胱肿瘤组织和膀胱内灌注,2小时后取活检进行电镜观察,并结合体视学计量原理进行观察和比较,证明两药主要对肿瘤细胞产生毒性作用,导致细胞变性坏死,而代谢性作用次之。且两药对肿瘤细胞形态学影响相似,毒性程度也无区别。用药后肿瘤表、中层细胞改变明显,而基底层细胞无明显改变。 Application of thiotepa and mitomycin C solution soaked in vitro human bladder tumor tissue and intravesical instillation, 2 hours after the biopsy for electron microscopy and combined with stereological metrological principles were observed and compared to prove that the two drugs mainly on the tumor Cells produce toxic effects, leading to cell degeneration and necrosis, and the second metabolic role. And the two drugs have similar effects on tumor cell morphology, and there is no difference in the degree of toxicity. Tumor table after treatment, the middle layer of cells changed significantly, while basal cells did not change significantly.