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用特异性放射免疫分析法测定33例肝硬化和20例健康人的血浆内皮素(Endothelin,ET)含量,并对其中25例肝硬化食管静脉曲张硬化治疗患者治疗前及后1,3,7天进行血浆ET动态观察。结果表明肝硬化伴食管静脉曲张出血组血浆ET明显高于腹水组分别为2.96±0.18gp/ml和2.07±0.23pg/ml,p <0.001;硬化治疗后1,3,7天血浆ET分别为2.93±0.13pg/ml,3.42±0.18gp/ml,3.92±0.20pg/ml,逐渐升高、与治疗前2.46±0.15pg/ml比较差异非常显著;并提示血浆ET升高梯度与食管静脉闭塞程度呈正相关,似可作为临床估计硬化治疗效果的一项指标。
The levels of endothelin (ET) in 33 cases of liver cirrhosis and 20 healthy people were determined by specific radioimmunoassay, and 25 cases of cirrhosis esophageal varices were treated before and after treatment with 1,3,7 Day plasma ET dynamic observation. The results showed that the plasma ET in cirrhotic patients with esophageal variceal bleeding was significantly higher than that of ascites patients (2.96 ± 0.18gp / ml and 2.07 ± 0.23pg / ml, p <0.001); ET at 1, 3 and 7 days after sclerotherapy were 2.93 ± 0.13pg / ml, 3.42 ± 0.18gp / ml, 3.92 ± 0.20pg / ml, and gradually increased, compared with 2.46 ± 0.15pg / ml before treatment, the difference was significant; and the plasma ET elevation gradient and esophageal vein occlusion The degree is positively correlated, it may be used as an index to evaluate the clinical effect of sclerotherapy.