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喹啉类药物仍是目前主要应用的抗疟药。有关喹啉类药物抗疟作用机制主要有如下理论 :增加疟原虫溶酶体内pH值 ,改变原虫生长环境 ;抑制溶酶体酶的活性 ,减少原虫生长所需的营养成分 ;与DNA双螺旋链相互作用或抑制DNA和RNA聚合酶从而抑制原虫增殖 ;抑制溶酶体内铁释放 ,减少原虫生长所需铁 ;与高铁血红素结合形成复合物或抑制血红素聚合酶使血红素游离 ,并对疟原虫产生毒作用
Quinoline drugs are still the main anti-malarial drugs currently used. The mechanism of anti-malarial effects of quinoline drugs mainly includes the following theories: increasing the pH value of Plasmodium lysosome in vivo, changing the growth environment of protozoa, inhibiting the activity of lysosomal enzyme and reducing the nutrients required for the growth of protozoan; Interaction or inhibition of DNA and RNA polymerase to inhibit protozoan proliferation; inhibition of intracellular lysosomal release of iron, reduce the protozoan iron required for growth; combined with hematin to form a complex or inhibit heme polymerase free hemoglobin, and malaria Protozoa produce toxic effects