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动脉粥样硬化的病因之一是由于脂肪、类脂及蛋白质代谢失调,胆固醇/磷脂比值失常,血中胆固醇含量增高,从而使胆固醇沉积于脉管壁内膜下,引起内膜增生,以致造成动脉粥样病变。因此,降低血胆固醇的药物对防治动脉粥样硬化具有重要的作用,国外对寻找此类药物也很注意,目前,除找到某些有效的降胆固醇、甘油三酸酯的药物以外,还发展了无降胆固醇作用,但对动脉粥样硬化病变脉管有治疗作用的药物。现一并简述如下:
One of the causes of atherosclerosis is dyslipidemia due to fat, lipids and proteins, an abnormal cholesterol / phospholipid ratio, and an increase in cholesterol levels in the bloodstream, thereby causing cholesterol to deposit in the lining of the vessel wall and cause intimal hyperplasia, resulting in Atherosclerosis. Therefore, drugs that lower blood cholesterol play an important role in the prevention and treatment of atherosclerosis, and foreign countries are also paying attention to finding such drugs. At present, in addition to finding some effective cholesterol-lowering and triglyceride-based drugs, No cholesterol-lowering effect, but atherosclerotic lesions vascular treatment of drugs. Now and briefly as follows: