妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)是一种妊娠期特有的并发症,大多数发生在妊娠中晚期,平均发病孕周为30周,有约11.5%发生在孕28周以前[1]。主要以肝功能异常及无皮损性瘙痒为特点,一般在妊娠结束这些症状会消失。病因及发生机理目前尚未完全阐明。ICP对母体影响甚小,但对胎儿影响极大,可造成胎儿窘迫、死胎 Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific complication, most of which occurs in the second and third trimesters with an average gestational age of 30 weeks and an estimated 11.5% at 28 weeks of gestation Previously [1]. Mainly to abnormal liver function and no skin lesions itching, usually at the end of pregnancy these symptoms will disappear. Etiology and pathogenesis has not yet been fully elucidated. ICP has little effect on the mother, but the impact on the fetus is extremely large, can cause fetal distress and stillbirth