AIM: To determine the incidence of appendiceal Crohn’s disease(CD) and to summarize the characteristic histologic features of appendiceal CD.METHODS: We reviewed the pathology files of 2179 appendectomy specimens from January 2007 to May2013. The computer-assisted retrieval search facility was utilized to collect specimens. We selected those cases that were diagnosed as CD or chronic granulomatous inflammation and defined the final diagnosis according to the histologic findings of CD, including transmural lymphocytic inflammation, non-caseating epithelioid granulomas, thickening of the appendiceal wall secondary to hypertrophy of muscularis mucosa,mucosal ulceration with crypt abscesses, mucosal fissures, and fistula formation. RESULTS: We found 12 cases(7 male and 5 female patients, with an average age of 29.8 years) of appendiceal CD. The incidence of appendiceal CD was 0.55%.The chief complaints were right lower quadrant pain,abdominal pain, lower abdominal pain, and diarrhea.The duration of symptom varied from 2 d to 5 mo.The histologic review revealed appendiceal wall thickening in 11 cases(92%), transmural inflammation in all cases(100%), lymphoid aggregates in all cases(100%), epithelioid granulomas in all cases(100%), mucosal ulceration in 11 cases(92%), crypt abscesses in 5 cases(42%), perforation in 2 cases(17%), muscular hypertrophy in 1 case(8%), neural hyperplasia in 5 cases(42%), and perpendicular serosal fibrosis in 8 cases(67%).CONCLUSION: A typical and protracted clinical course, unusual gross features of the appendix and the characteristic histologic features are a clue in the diagnosis of appendiceal CD. AIM: To determine the incidence of appendiceal Crohn’s disease (CD) and to summarize the characteristic histologic features of appendiceal CD. METHODS: We reviewed the pathology files of 2179 appendectomy specimens from January 2007 to May 2013. The computer-assisted retrieval search facility was to collect specimens. We selected those cases that were diagnosed as CD or chronic granulomatous inflammation and defined the final diagnosis according to the histologic findings of CD, including transmural lymphocytic inflammation, non-caseating epithelioid granulomas, thickening of the appendiceal wall secondary to hypertrophy of RESULTS: We found 12 cases (7 male and 5 female patients, with an average age of 29.8 years) of appendiceal CD. The incidence of appendiceal CD was 0.55% The chief complaints were lower right quadrant pain, abdominal pain, lower abdominal pain, and diarrhea.The du The rationality of symptom varied from 2 days to 5 months. The histologic findings revealed appendiceal wall thickening in 11 cases (92%), transmural inflammation in all cases (100%), lymphoid aggregates in all cases (100%), epithelioid granulomas in all cases (100%), mucosal ulceration in 11 cases (92%), crypt abscesses in 5 cases (42%), perforation in 2 cases (17%), muscular hypertrophy in 1 case (42%), and perpendicular serosal fibrosis in 8 cases (67%). CONCLUSION: A typical and protracted clinical course, unusual gross features of the appendix and the characteristic histologic features are a clue in the diagnosis of appendiceal CD.