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动物毒素是指有毒动物毒器分泌的毒液中,结构和功能丰富多样的蛋白质和多肽,其具有高活力、高结构多样性、高专一性等特点,是药物开发的重要资源。综述了动物毒素药物的特点以及进入临床药物和候选药物分子的研究进展,同时分析了我国动物毒素类药物研发中需要重视的问题。
Animal toxins refers to the venom secreted by poisonous animal toxins, rich in structure and function of various proteins and peptides, with high activity, high structural diversity, high specificity and other characteristics, is an important resource for drug development. In this paper, the characteristics of animal toxins and their progress in clinical drug and candidate drug molecules are reviewed. At the same time, the problems that need attention in the research and development of animal toxins in China are analyzed.