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采用杯碟法、微量生物量热法,研究了8-羟基喹啉-水杨酸-镧配合物(La(C_7H_5O_3)_2·(C_9H_6NO))对金黄色葡萄球菌(Staphylococcus aureus,CICC10384)、枯草芽孢杆菌(Bacillus subtilis,CICC10012)、大肠杆菌(Escherichia coli,s ATCC8739)、粟酒酵母(Schizosaccharomyces pombe)及K562和He La-60肿瘤细胞的抑制活性。结果表明:La(C_7H_5O_3)_2·(C_9H_6NO)对3种细菌的最小杀菌浓度分别为0.45~0.90 g/L、1.2~1.5 g/L和1.2~1.5 g/L,而且浓度1.5 g/L以上的稀土配合物对3种细菌的抑制作用存在极显著差异(P<0.01),其中3.6 g/L以上浓度的稀土配合物对3种细菌的抑菌达到了强、中、强的效果;对S.pombe、K562细胞、He La-60细胞也都具有较强的抑制作用,且IC50分别为26.77 mg/L、1.62 mg/L和1.68 mg/L。以上结果说明,La(C_7H_5O_3)_2·(C_9H_6NO)具有较强的抑菌和抗肿瘤效果。
The effects of 8-hydroxyquinoline-salicylic acid-lanthanum complex (La (C_7H_5O_3) _2 · (C_9H_6NO)) on Staphylococcus aureus (CICC10384) Inhibitory activity of Bacillus subtilis (CICC10012), Escherichia coli (ATCC8739), Schizosaccharomyces pombe, and K562 and He La-60 tumor cells. The results showed that the minimum bactericidal concentrations of La (C_7H_5O_3) _2 · (C_9H_6NO) were 0.45 ~ 0.90 g / L, 1.2 ~ 1.5 g / L and 1.2 ~ 1.5 g / L, (P <0.01). The rare earth complexes with the concentration above 3.6 g / L had strong, moderate and strong inhibitory effects on the three kinds of bacteria. S.pombe, K562 cells and He La-60 cells also have strong inhibitory effect, and the IC50 were 26.77 mg / L, 1.62 mg / L and 1.68 mg / L, respectively. The above results show that La (C_7H_5O_3) _2 · (C_9H_6NO) has strong antibacterial and antitumor effects.