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随着各种生物材料的应用,慢性感染及医源性感染日益突出,凝固酶阴性球菌-表皮葡萄球菌成为首要病原体,它主要致病机制是生物膜形成,生物膜形成则成为生物材料感染难以控制的根源。细菌生物膜是具有高度组织化的多细胞群体结构,它们间相互通讯,有着精密的调控机制以适应不同的环境,能有效抵御机体的防御反应和抗生素治疗。随着对生物膜分子水平研究的不断深入,为临床防治生物膜相关性感染提供了更有效的靶点。
With the application of various biological materials, chronic infection and iatrogenic infection have become increasingly prominent, coagulase-negative bacteria - Staphylococcus epidermidis become the primary pathogen, its main pathogenic mechanism is biofilm formation, biofilm formation becomes difficult to bio-material infection The root of control. Bacterial biofilm is a highly organized multicellular population structure, they communicate with each other, with sophisticated regulatory mechanisms to adapt to different environments, can effectively resist the body’s defensive response and antibiotic treatment. With the further research on the molecular level of biofilm, it provides a more effective target for clinical prevention and treatment of biofilm-related infections.