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经病理确诊的47例乙型肝炎患者血清中HBV DNA、HBeAg的检出率在各型肝炎之间无显著性差异(P>0.05)。肝组织HBsAg检出率为76.6％,其形态呈包涵体型、弥漫型和膜型为主分布者分别是36.1％、55.6％和8.3％。HBsAg呈弥漫型分布者各类型肝炎之间无显著性差异(P>0.05),提示肝细胞内HBsAg的表达仅反映HBV复制,而与肝组织病变无关。肝组织HBcAg检出率为27.7％,其形态呈核型和浆型分布者分别占38.5％和61.5％,浆型主要见于炎症明显的肝细胞内,而核型刚见于病变较轻的肝细胞中,反映了HBcAg的表达与肝组织活动性病变有关。
Pathological diagnosis of 47 cases of hepatitis B serum HBV DNA, HBeAg detection rate in the various types of hepatitis between no significant difference (P> 0.05). The detection rate of HBsAg in liver tissue was 76.6%, and its shape was inclusion body type. The main distribution of diffuse and membranous type was 36.1%, 55.6% and 8.3% respectively. There was no significant difference (P> 0.05) among all types of hepatitis with diffuse distribution of HBsAg, suggesting that the expression of HBsAg in hepatocytes only reflects HBV replication, but not with the liver lesions. The detection rate of HBcAg in liver tissue was 27.7%, with 38.5% and 61.5% in the distribution of karyotype and plasma type, respectively. The type of plasma was mainly found in the hepatocytes with obvious inflammation, while the karyotype was just found in the lesion-less hepatocytes In, reflecting the expression of HBcAg and liver tissue activity of the disease.