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目的:探讨血清胱抑素-C(Cys-C)在评估高胆红素血症早产儿肾功能损伤中的价值。方法:选择113例早产儿为研究对象,按胆红素程度分为轻度组(25例)、中度组(15例)及重度组(11例),其中胆红素在正常范围者为对照组(62例)。所有早产儿在生后3天至1周内抽取静脉血2 ml,采用免疫比浊法检测血清Cys-C水平,同时检测血清尿素氮(BUN)及肌酐(Cr)。应用SPSS 11.0软件进行统计学分析。结果:重度组与对照组、中度组与对照组患儿之间血清Cys-C的差异均有统计学意义(P<0.01);重度组与中度组、重度组与轻度组、中度组与轻度组患儿之间血清Cys-C的差异均有统计学意义(P<0.01);轻度组与对照组间血清Cys-C的差异无统计学意义(P>0.05);各组间血清BUN及Cr的差异无统计学意义(P>0.05)。结论:血清Cys-C能较早发现早产儿高胆红素血症的肾功能损害,可作为高胆红素血症早产儿肾功能损害早期诊断指标之一,且敏感性优于血清BUN和Cr。
Objective: To investigate the value of serum cystatin C (Cys-C) in assessing renal dysfunction in preterm infants with hyperbilirubinemia. Methods: A total of 113 preterm infants were selected as study subjects and divided into mild group (n = 25), moderate group (n = 15) and severe group (n = 11) according to the level of bilirubin. Control group (62 cases). All preterm infants were given venous blood 2 ml 3 days to 1 week after birth. Serum Cys-C level was measured by immunoturbidimetry. Serum urea nitrogen (BUN) and creatinine (Cr) were measured simultaneously. SPSS 11.0 software was used for statistical analysis. Results: There was significant difference in serum Cys-C between severe group and control group, moderate group and control group (P <0.01); severe group and moderate group, severe group and mild group There was significant difference in serum Cys-C between degree group and mild degree group (P <0.01). There was no significant difference in serum Cys-C between mild degree group and control group (P> 0.05). There was no significant difference in serum BUN and Cr among the three groups (P> 0.05). Conclusion: Serum Cys-C can be early detection of premature children with hyperbilirubinemia renal dysfunction, as an early diagnosis of hyperbilirubinemia premature children renal dysfunction, one of the indicators, and the sensitivity is better than the serum BUN and Cr.