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目的:观察苦参抑菌洗液对家兔皮肤的反应情况,为临床安全用药提供依据。方法:按照卫生部《消毒技术规范》(2002版),采用急性皮肤刺激试验和多次皮肤刺激试验。结果:肉眼观察苦豆子抑菌洗液对急性皮肤及多次皮肤给药刺激改变,兔子皮肤均出现了不同程度的红斑、水肿。急性皮肤刺激试验的刺激指数为3.7,多次皮肤刺激试验的刺激指数为5.5。结论:苦豆子抑菌洗液对大白兔急性皮肤刺激强度和多次皮肤刺激强度均为中等刺激性。
Objective: To observe the reaction of Sophora flavescens antibacterial lotion to skin of rabbits, and provide basis for clinical safety medication. Methods: According to “Disinfection Technical Specification” of the Ministry of Health (2002 edition), acute skin irritation test and multiple skin irritation test were used. Results: Macroscopic observation of the anti-bacterial lotion of Sophora flavescens stimulates the changes of acute skin and multiple skin administrations. The erythema and edema of rabbits skin appear to varying degrees. The irritation index for the acute skin irritation test was 3.7 and the stimulation index for the multiple skin irritation test was 5.5. Conclusion: The anti-bacterial lotion of Sophora alopecuroides is moderate irritant to acute skin irritation and repeated skin irritation in rabbits.