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目的探讨川芎嗪对糖尿病肾病（ＤＮ）的疗效。方法７１例ＤＮ患者中，早期ＤＮ组３３例，临床ＤＮ肾功能正常组２１例，临床ＤＮ肾衰组１７例，每组患者分为治疗组和对照组。除常规治疗外，各治疗组加用川芎嗪静脉点滴，于治疗前后检测血糖、血肌酐、ＢＵＮ和尿蛋白排泄量。统计学处理采用ｔ检验及Ｘ２检验。结果与对照组相比，川芎嗪可使早期ＤＮ患者和临床ＤＮ肾功能正常的患者尿蛋白排泄量明显减少（Ｐ＜０．０１），两组总有效率分别是９５．２４％和８４．２６（Ｐ＜０．０５）。川芎嗪治疗对血肌酐、ＢＵＮ、血压无显著影响。结论川芎嗪对早期ＤＮ和肾功能正常的临床ＤＮ有显著疗效。
Objective To investigate the curative effect of ligustrazine on diabetic nephropathy (DN). Methods Thirty-one patients with DN were divided into three groups: early DN group (n = 21), clinical DN renal dysfunction group (n = 21) and clinical DN renal failure group (n = 17). Each group was divided into treatment group and control group. In addition to conventional treatment, each treatment group with intravenous infusion of ligustrazine, before and after treatment to detect blood glucose, serum creatinine, BUN and urinary protein excretion. Statistical analysis using t test and X2 test. Results Compared with the control group, tetramethylpyrazine significantly reduced urinary protein excretion (P <0.01) in patients with early DN and DN with normal renal function, the total effective rates were 95.24% and 84% respectively. 26 (P <0.05). Ligustrazine treatment of serum creatinine, BUN, blood pressure had no significant effect. Conclusion Tetramethylpyrazine has a significant effect on early DN and clinical DN with normal renal function.