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乳腺癌病因至今未明。目前主要有两个假说:一为病毒说,该说得到某些动物实验的支持,但缺乏人类流行病学的证据;另一为内分泌说,认为乳腺癌的发生与雌激素有关。有些动物实验指出,雌酮和雌二醇是致癌促癌的因素,而睾酮在乳腺肿瘤发生前有延缓和抑制肿瘤发生的作用,但对已发生的肿瘤无保护作用。人类流行病学调查材料显示,乳癌与月经生育史有关。MacMahon和Zumoff等人研究了大量流行病学材料后指出,从青春期到30岁前,雌激素各组分的水平是决定妇女一生患乳癌危险性
The cause of breast cancer is still unknown. Currently there are two main hypotheses: one for the virus, said that some animal experiments that support the lack of evidence of human epidemiology; the other is endocrine said that the occurrence of breast cancer and estrogen. Some animal experiments show that estrone and estradiol are carcinogenic and carcinogenic factors, and testosterone in breast cancer before the delay and inhibition of tumorigenesis, but no protective effect on the tumor has occurred. Human epidemiological survey data show that breast cancer and menstrual history of fertility. MacMahon and Zumoff, who studied a large number of epidemiological materials, pointed out that from adolescence to the age of 30, the level of estrogen components is to determine the risk of breast cancer in women’s lives