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许多研究发现早期ARDS患者肺泡灌洗液(BALF)中炎症细胞因子(ICs)的水平明显升高,而ICs也是组织损伤和修复的重要调节物质。作者通过前瞻性观察ARDS患者肺损伤程度(肺损伤评分等)、肺泡毛细血管内皮通透性改变(BALF中自蛋白、总蛋白含量)及患者预后,测定BALF及血浆中ICs浓度,探讨重度ARDS时ICs与肺泡毛细血管屏障破坏及增生修复的关系。 27例严重ARDS患者纳入观察组,记录APACHEⅡ评分、Murry急性肺损伤评分(LIS)、MODS评分、ARDS诱因及患者转归等资料。其中22例在ARDS发生第1天即通过支气管镜分别留取双侧BALF,测定
Many studies have found that levels of inflammatory cytokines (ICs) in BALF in patients with early ARDS are significantly elevated, and ICs are also important regulators of tissue damage and repair. The prospective observation of ARDS patients with lung injury (lung injury score, etc.), changes in alveolar capillary endothelial permeability (BALF self-protein, total protein content) and prognosis of patients with BALF and plasma concentrations of ICs to explore the severity of ARDS Relationship between ICs and Alveolar Capillary Barrier Damage and Proliferation and Repair. Twenty-seven patients with severe ARDS were enrolled in the observation group. APACHEⅡscore, Murry acute lung injury score (LIS), MODS score, ARDS causes and patient outcomes were recorded. Twenty-two of them had left bilateral BALF by bronchoscopy on the first day of ARDS,