【摘 要】
：
目的:探讨精神分裂症患者感觉门控电位P50和惊跳反射弱刺激抑制(PPI)的特征以及两者的相关性.方法:选取符合美国精神障碍诊断与统计手册第4版(DSM-Ⅳ)的精神分裂症患者78例,
【基金项目】
：
首都医学发生科研基金;国家自然科学基金;北京市优秀人才培养资助;北京市医院管理局临床医学发展专项
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目的:探讨精神分裂症患者感觉门控电位P50和惊跳反射弱刺激抑制(PPI)的特征以及两者的相关性.方法:选取符合美国精神障碍诊断与统计手册第4版(DSM-Ⅳ)的精神分裂症患者78例,正常对照90例,使用阳性和阴性症状量表(PANSS)评定精神分裂症患者的临床精神病理症状;使用脑电生理记录仪,采用听觉条件(S1)-测试(S2)刺激范式进行P50检测;使用SR-HLAB惊跳反射监控系统测查听觉惊跳反射.结果:精神分裂症组的S1波幅低于对照组[(2.9±1.7)μVvs.(3.7±2.0)μV,P ＜0.05];S2波幅高于对照组[(2.0±1.2)μVvs.(1.4±1.5) μV,P＜0.001];P50抑制率比值(S2/S1)精神分裂症组高于对照组[(0.8±0.5)vs.(0.4±0.4),P＜0.001],P50抑制率差值(S1-S2)低于对照组[(0.9±1.7)vs.(2.3±1.8),P ＜0.001].精神分裂症组的惊跳反射的波幅低于对照组[(1037.5±1048.6) ms vs.(1367.7±952.3)ms,P＜0.001],习惯化百分比亦低于对照组[(33.9±20.8)％ vs.(48.8±34.7)％,P=0.002];精神分裂症组的PPI60和PPI120均低于对照组[(24.1±9.1)％vs.(29.8±11.5)％,P =0.020;(31.2±10.1)％ vs.(42.6±15.4)％,P＜0.001].在精神分裂症组中,P50各项分析指标与PPI各项分析指标间的相关性无统计学意义(P＞0.05),P50与PPI各项分析指标与PANSS总分、PANSS阳性症状总分、PANSS阴性症状总分间的相关性无统计学意义(P＞0.05);在对照组中,惊跳反射的波幅与s1波幅与s2波幅呈正相关(r=0.28、0.27,均P＜0.05).结论:精神分裂症患者可能存在感觉门控的缺陷,P50和PPI缺陷与临床精神病理症状的严重程度可能无关,反映感觉门控的两种测量模式P50和PPI间可能无相关性,二者可能相互独立.
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