患者与方法 选择10例重型再生障碍性贫血(SAA)的儿童,年龄1～13岁;男6例,女4例;诊断至开始重组人粒细胞集落刺激因子(rhG-CSF)治疗中位间隔期为9周(6～26);患儿的中性粒细胞绝对值(NAC)均低于0.05×10~9/L,其中5例缺乏循环中性粒细胞,8例合并细菌或霉菌感染。rhG-CSF的治疗方案包括4种剂量(400、800、12O0和2000μg/m~2/d),30分钟内静脉输入,每天1次,共28天。接受大剂量rhG-CSF后头14天无造血反应者于后14 Patients and Methods Ten children with severe aplastic anemia (SAA) aged 1 to 13 years, including 6 males and 4 females, were enrolled in this study. The median time from diagnosis to initiation of rhG-CSF treatment The median neutrophil count (NAC) was less than 0.05 × 10 ~ 9 / L in 9 children (6 ~ 26), of which 5 patients had no circulating neutrophils and 8 patients had bacterial or fungal infection . Treatment regimens for rhG-CSF included four doses (400, 800, 12 O0 and 2000 μg / m2 / d) intravenously over 30 minutes once daily for 28 days. After receiving large doses of rhG-CSF in the first 14 days no hematopoietic response in the latter 14