论文部分内容阅读
目的:探讨斯钙素(stanniocalcin-1,STC-1)在食管鳞癌(Esophageal squamous cell carcinoma,ESCC)患者骨髓中的表达及其临床意义。方法:术中收集85例ESCC患者肋骨骨髓,应用巢式RT-PCR检测STC-1 mRNA的表达,并分析其与临床病理特征及两年无进展生存(Progress Free Survival,PFS)的关系。结果:骨髓STC-1 mRNA阳性率为21.2%(18/85)。STC-1阳性与患者临床分期(P=0.013)及淋巴结转移(P=0.029)相关,其2年PFS(平均15.0月)亦劣于STC-1阴性者(平均19.7月)(P=0.003)。结论:骨髓STC-1 mRNA检测对于判断ESCC微转移具有重要意义,可望成为ESCC潜在预后标志物。
Objective: To investigate the expression of stanniocalcin-1 (STC-1) in the bone marrow of patients with esophageal squamous cell carcinoma (ESCC) and its clinical significance. METHODS: The bone marrow of 85 patients with ESCC were collected during operation. The expression of STC-1 mRNA was detected by nested RT-PCR and its relationship with clinicopathological features and progression-free survival (PFS) was analyzed. Results: The positive rate of bone marrow STC-1 mRNA was 21.2% (18/85). The positive STC-1 was also associated with clinical stage (P = 0.013) and lymph node metastasis (P = 0.029). The 2-year PFS (mean 15.0 months) was also lower than that of STC- . Conclusion: The detection of bone marrow STC-1 mRNA is of great significance in judging the micrometastasis of ESCC, and it is expected to be a potential prognostic marker of ESCC.