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目的:探讨厄贝沙坦联合氨氯地平治疗2型糖尿病合并高血压的临床疗效。方法:选取2012年1月至2014年1月泸西县人民医院收治的2型糖尿病合并高血压患者80例,随机分为观察组和对照组各40例,两组患者均在平稳控制血压的基础上给予厄贝沙坦片治疗,观察组在此基础上加用氨氯地平治疗,比较两组疗效。结果:观察组治疗后的血压下降情况明显优于对照组(P<0.05);两组治疗前后空腹血糖无明显变化(P<0.05),但观察组胰岛素抵抗指数明显小于对照组(P<0.05);观察组治疗总有效率为85.0%,明显大于对照组(P<0.05)。结论:厄贝沙坦与氨氯地平联合治疗2型糖尿病合并高血压疗效显著。
Objective: To investigate the clinical efficacy of irbesartan combined with amlodipine in the treatment of type 2 diabetes mellitus complicated with hypertension. Methods: From January 2012 to January 2014, Luxi County People’s Hospital admitted 80 cases of type 2 diabetes mellitus with hypertension, were randomly divided into observation group and control group, 40 cases in both groups were in stable control of blood pressure On the basis of irbesartan tablets treatment, the observation group on this basis plus amlodipine treatment, the efficacy of the two groups were compared. Results: The decrease of blood pressure after treatment in observation group was better than that in control group (P <0.05). There was no significant difference in fasting blood glucose between two groups before and after treatment (P <0.05), but insulin resistance index in observation group was significantly lower than that in control group ). The total effective rate of observation group was 85.0%, which was obviously higher than that of control group (P <0.05). Conclusion: The combination of irbesartan and amlodipine in the treatment of type 2 diabetes mellitus with hypertension has a significant effect.