【摘 要】
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BACKGROUND AND OBJECTIVEPrevious studies have demonstrated an association between longer working hours and the risk of coronary heart disease, myocardial infarction, cardiac arrhythmias and stroke. Th
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BACKGROUND AND OBJECTIVEPrevious studies have demonstrated an association between longer working hours and the risk of coronary heart disease, myocardial infarction, cardiac arrhythmias and stroke. This study assessed the effect of long working hours on the risk of deep venous thrombosis (DVT) or pulmonary embolism (PE)．
METHODSData were obtained from the Individual Participant Data Meta-Analysis in Working Populations (IPD-Work) consortium, including data from 13, independent cohort studies in multiple nations. Long working hours were defined as 55 hours per week or longer, and standard working hours as 35 to 40 hours per week. The subjects were followed for incident venous thromboembolisms (VTE). The sample was followed for a mean of 9.7 years, with work hours compared to the incidence of VTE.
RESULTSAmong the 77，291, full-time employees included in the analysis, 539 first-time VTE events were recorded, with an incidence of 64.9 per 100，000 person/years. Compared to those working 35 to 40 hours per week, the risk of VTE was greater among those with longer working hours (HR 1.5). The risk with longer hours was greater for DVT (HR 1.7) than for PE (HR 1.4)．
CONCLUSIONThis study expands on our understanding of the cardiovascular risks of working 55 hours per week or longer, demonstrating an increased risk of venous thromboembolism.
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