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目的:寻找难治性复发性急性髓系白血病(AML)患者有效治疗途径。方法:应用阿克拉霉素(ACR)、阿糖胞苷(Ara-C)、粒系集落刺激因子(rhG-CSF)组成CAG方案,治疗难治性AML 4例、复发性AML5例。1个疗程未取得完全缓解者,可接受第2疗程的治疗。同时患者接受一般对症支持治疗。结果:9例中,CR 3例,PR 3例,MR3例,总有效率66.7 %。主要毒副反应是骨髓抑制,其他非血液学毒性表现较轻。治疗期间无治疗相关性死亡病例。结论:CAG方案对难治性复发性AML患者有积极的治疗作用,治疗过程中感染、出血等并发症少,特别是对老年患者有明显的优点。
Objective: To find an effective treatment for patients with refractory recurrent acute myeloid leukemia (AML). Methods: Four cases of refractory AML and five cases of recurrent AML were treated with aclacinomycin (ACR), Ara-C and rhG-CSF. A course of treatment has not been completely relieved, can be the first two courses of treatment. At the same time, patients receive general symptomatic supportive care. Results: Of the 9 cases, 3 were CR, 3 were PR, and 3 were MR. The total effective rate was 66.7%. The main toxicities are myelosuppression, other non-hematologic toxicities are less severe. No treatment-related deaths occurred during treatment. Conclusion: The CAG regimen has a positive therapeutic effect on patients with refractory recurrent AML. There are few complications such as infection and bleeding during the course of treatment, especially for elderly patients.