作者报告了10名患中度急性恶性疟的越南儿童口服青蒿琥酯的药物动力学研究结果。病儿年龄6—15岁,治前均未服用任何抗疟药物。在病人前臂静脉维持插管。病人口服青蒿琥酯3mg/kg。服药前及服药后的0.25,0.5,1,2,3,4,6,8,10,12和24h自插管抽取血液各1ml,离心取血浆,立即冰冻保存。自第24h起,每日给青蒿琥酯2mg/kg一 The authors report the pharmacokinetic results of oral artesunate administered to 10 Vietnamese children with moderate acute falciparum malaria. Sick children aged 6-15 years old, did not take any antimalarial drugs before treatment. Maintain the cannula in the patient’s forearm vein. Patient oral artesunate 3mg / kg. Before taking the drug and taking 0.25, 0.5, 1, 2, 3, 4, 6, 8, 10, 12 and 24h after taking the blood from the cannula 1ml, centrifuged plasma, immediately frozen. From the first 24h, artesunate 2mg / kg daily