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目的 研究铝接触对工人脂质过氧化水平的影响。方法 选取某铝厂工人 6 5人 ,观察血清铝、尿铝浓度 ,血清中谷胱甘肽过氧化物酶 (GSH Px)活力、丙二醛 (MDA)含量及红细胞中超氧化物歧化酶(SOD)活力的变化情况。结果 作业环境氧化铝粉尘时间加权几何平均浓度为 13.4mg/m3 (4.5～ 38.6mg/m3 ) ,铝接触组血清铝 (74 .0 8μg/L)和尿铝 (30 .5 1μg/L)浓度明显高于对照组 (血清铝 2 7.38μg/L、尿铝8.11μg/L) ;血清GSH Px活力降低 (分别为 95 .0 2U/ 0 .1ml和 14 2 .97U/ 0 .1ml) ,血清MDA含量增高 (分别为 6 .72nmol/L和 4 .2 8nmol/L) ,红细胞中SOD活力增高 (分别为 2 2 5 6 2 .39、195 2 3.2 8NU/ml) ,差异有显著性 (P <0 .0 0 1) ;血清铝、尿铝浓度皆与血清GSH Px活力呈负相关 ,且均与血清MDA含量及红细胞中SOD活力呈正相关。结论 铝接触工人脂质过氧化水平升高 ,SOD活力升高可能是机体为保护组织免受脂质过氧化损伤的代偿作用
Objective To study the effect of aluminum exposure on lipid peroxidation in workers. Methods A total of 65 workers in an aluminum factory were selected to study the effects of serum aluminum and urine aluminum concentration, GSH Px, MDA and erythrocyte superoxide dismutase (SOD) Vibrant changes. Results The time-weighted geometric mean concentrations of alumina dust were 13.4 mg / m3 (4.5 ~ 38.6 mg / m3) in the working environment, 74.88 μg / L in the aluminum exposure group and 30.51 μg / L in the aluminum exposure group Was significantly higher than the control group (serum aluminum 2 7.38μg / L, urine aluminum 8.11μg / L); serum GSH Px activity decreased (95.022U /0.1ml and142.97U / 0.1ml), serum The MDA content increased (6 .72nmol / L and4.28nmol / L respectively), and the activity of SOD in erythrocytes increased (2 526.239,195 2 3.2 8NU / ml), the difference was significant (P <0 01). Serum aluminum and urine aluminum concentrations were negatively correlated with serum GSH Px activity, and both were positively correlated with serum MDA level and SOD activity in erythrocytes. Conclusion The levels of lipid peroxidation and the activity of SOD in aluminum exposure workers may be the compensatory role of the body in protecting tissues from lipid peroxidation injury