肺纤维化(pul monary fibrosis,FP)主要是由于各种刺激性因子如矿物粉尘、氧化性气体等作用于肺组织引起的以大量成纤维细胞聚集、细胞外基质(Extracellular matrix ECM)沉积为特征并伴有炎症细胞浸润(单核-巨噬细胞、中性粒细胞、淋巴细胞)和损伤而导致正常的肺组织结构和功能 Pulmonary fibrosis (FP) is mainly caused by the accumulation of a large number of fibroblasts and the extracellular matrix ECM deposition caused by various stimulating factors such as mineral dust and oxidizing gas acting on the lung tissue Accompanied by inflammatory cell infiltration (monocytes - macrophages, neutrophils, lymphocytes) and damage resulting in normal lung tissue structure and function