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为探讨Ｂｃｌ－２蛋白在子宫内膜腺癌组织中的表达状况，其病理学与临床意义，本组应用抗Ｂｃｌ－２单克隆抗体对３４例子宫内膜腺癌组织石蜡标本行Ｂｃｌ－２蛋白免疫组织化学测定（ＳＡＢＣ法）。结果发现Ｂｃｌ－２蛋白在子宫内膜腺癌组织中表达的阳性率为４７％，其阳性表达与肿瘤组织学分级、肌层浸润深度及患者预后有关（Ｐ＜００５）。说明Ｂｃｌ－２蛋白表达与子宫内膜腺癌的某些病理学特征及生物学行为之间存在关系。应用ＳＡＢＣ法测定Ｂｃｌ－２蛋白表达对判断子宫内膜腺癌患者的预后有一定价值。
To investigate the expression of Bcl-2 protein in endometrial adenocarcinoma and its pathological and clinical significance, this group of anti-Bcl-2 monoclonal antibody on 34 cases of endometrial adenocarcinoma tissue paraffin specimens Bcl-2 Protein immunohistochemistry (SABC method). The positive rate of Bcl-2 protein expression in endometrial adenocarcinoma was 47%. The positive expression of Bcl-2 protein was correlated with histological grade, depth of myometrial invasion and prognosis (P <005). This suggests that there is a relationship between the expression of Bcl-2 protein and some pathological features and biological behavior of endometrial adenocarcinoma. SABC assay of Bcl-2 protein expression in the judgment of prognosis of endometrial adenocarcinoma has some value.