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Obiective:To observe the effect of Ljdan Granule(利胆冲剂,LDG)on bile lithogenic tendency and biliary 33.5 kd vesicular protein(VP)and to explore its mechanism.Methods:Sixty patients with choledocholithiasis combined with cholecystolithiasis were randomly assigned to the LDG treated group,the sodium cholate treated group for positive control,and the untreated control group,20 patients in each group.The 4 bile lithogenic trend indexes,including lithogenic index(LI),unconjugated bilirubin percent(UCB%),unconjugated bilirubin saturation index(BSI)and Z-value,were determined before and after treatment.The content of VP in bile was determined as well.Results:Before treatment,the LI,UCB%,BSI and Z-value in the LDG treated group were 1.298±0.265,34.72±2.96,0.353±0.093 and 0.556±0.499,respectively,which was decreased after the 2-week treatment to 0.926±0.208,8.93±1.19,0.154±0.056 and 0.257±0.211,respectively(all P＜0.05).Meantime.the content of VP was also lowered from 0.050±0.005 g/L to 0.032±0.005 g/L.However.no significant change in any of the above-mentioned indexes was found in the other two groups.Conclusion:LDG could effectively suppress bile lithogenic trend and reduce 33.5 kd VP in bile.