肾母细胞瘤，即Ｗｉｌｍｓ’瘤，是儿童泌尿系统最常见的肿瘤，是后肾胚间质异常增殖，未能分化成肾小管和肾小球所致。 Ｃａｌｌ 等人在染色体 １１ｐ１３位点分离到一个与肾母细胞瘤有关的基因－ＷＴ１（Ｗｉｌｍｓ’ ｔｕｍｏｒ ｇｅｎｅ－ １）。 ＷＴ１是抑癌基因，其ｍＲ Wilms tumor, Wilms’ tumor, is the most common tumor in children’s urinary system. It is caused by the abnormal proliferation of the interstitium of the re-kidney and its failure to differentiate into tubules and glomerulus. Call et al. Isolated a Wilms ’tumor gene-1 gene associated with Wilms’ tumor at chromosome 11p13. WT1 is a tumor suppressor gene whose mR