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目的探讨儿童短暂性抽动障碍与血铅水平的关系。方法 测定180例短暂性抽动症患儿及160例正常儿童的血铅浓度;将180例短暂性抽动症患儿中58例铅中毒的抽动症患儿按1:1的比例随机分成A、B两组,A组先用鹿珠合剂进行驱铅治疗,同期B组用(谷维素+肌苷片)治疗,经一个月的治疗期后,A、B两组再交换药物治疗一个月,B组使用鹿珠合剂驱铅治疗,A组再同期使用(谷维素+肌苷片)治疗。在每个治疗期末观察两组患者的抽动类型、抽动频率、抽动强度以及对生活的影响,采用耶鲁抽动症整体严重度量表(YGTSS)在治疗期前后对两组进行临床症状评分,并且测定各治疗期患者的血铅浓度。结果对180例短暂性抽动症患儿及160例正常儿童的血铅测定中发现,抽动症患儿平均血铅浓度为84.73μg/L,正常儿童的平均血铅浓度为49.1μg/L,抽动症患儿的血铅水平明显高于正常儿童(P<0.05)。58例铅中毒的抽动症患儿在不同顺序治疗的治疗期末,患者的临床症状均得到改善,但血铅水平仅在鹿珠合剂驱铅治疗后有明显下降。在对血铅中毒的短暂性抽动症患儿进行鹿珠合剂驱铅治疗的过程中,血铅水平下降的同时,抽动症状也得到相应的控制。结论有短暂性抽动障碍的孩子血铅水平高于正常儿童,且血铅中毒的短暂性抽动症患儿在驱铅治疗的同时抽动症状得到相应的改善,因此儿童抽动障碍与血铅有一定的相关性。
Objective To investigate the relationship between transient tic disorder and blood lead level in children. Methods 180 cases of transient tic disorder children and 160 normal children blood lead concentrations were measured; 180 children with transient tic disorder 58 cases of lead poisoning tic disorder children were randomly divided into 1: 1 ratio of A, B In both groups, group A was treated with deer beads for lead treatment first, while group B was treated with oryzine (with oryzine) over the same period. After one month of treatment, groups A and B were exchanged for another month, group B Deer beads mixture used to drive lead treatment, A group and then use the same period (oryzanol + inosine tablets) treatment. At the end of each treatment period, the type of twitch, twitch frequency, twitching strength and the impact on life were observed in both groups. Clinical symptom scores of both groups were measured before and after treatment with Yale’s Tourette Total Seruity Scale (YGTSS) Blood lead levels in patients during treatment. Results In 180 children with transient tic disorder and 160 normal children, the blood lead level was found to be 84.73μg / L in children with tic disorder, and 49.1μg / L in normal children The level of blood lead in children with disease was significantly higher than that in normal children (P <0.05). 58 cases of lead poisoning tic disorder in patients with different sequential treatment of the treatment period, patients with clinical symptoms have been improved, but the blood lead levels only in deer beads mixture after lead treatment significantly decreased. During the treatment of dexamethasone in children with transient tic disorder due to blood lead poisoning, the level of blood lead decreased and tic symptoms were also controlled accordingly. Conclusions The level of blood lead in children with transient tic disorder is higher than that in normal children, and the tic disorder in children with tangled lead poisoning is improved at the same time. Therefore, children with tic disorder have a certain Correlation.