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活动性SLE患者伴有肾炎和/或血小板减少时,周围血辅助性T淋巴细胞(Th)百分比降低,T抑制性T淋巴细胞(Ts)百分比升高,Th与Ts之比率降低。近来发现,皮质类固醇类药物可引起类似SLE肾炎的T细胞亚群变化,且可以发生在正常个体身上。本文测定了未经任何治疗的SLE患者T淋巴细胞亚群的分布,同时还检查了SLE肾炎患者血清中抗体,发现活动性SLE肾炎患者血清中存在IgM抗T细胞毒性抗体。病人及对照者:12例女性活动性SLE患者(21～43岁),其中8例伴有活动性肾炎(7例做了经皮肾穿)。所有患者血清肌酐正常,试验时无一例接受治疗。以14例健康者做对照(男性8例,女性6例,27～45岁)。
In patients with active SLE with nephritis and / or thrombocytopenia, the percentage of peripheral blood helper T-lymphocytes (Th) decreases, the percentage of T-suppressor T lymphocytes (Ts) increases, and the ratio of Th to Ts decreases. Recently, corticosteroids have been found to cause changes in T-cell subsets similar to SLE nephritis and can occur in normal individuals. This paper measured the distribution of T lymphocyte subsets in patients with SLE without any treatment and also examined the serum antibodies in patients with SLE nephritis and found that IgM anti-T cytotoxic antibodies were present in the serum of patients with active SLE nephritis. Patients and controls: Twelve women with active SLE (21-43 years), of whom 8 had active nephritis (7 had percutaneous renal access). Serum creatinine was normal in all patients and none of the patients were treated during the trial. In 14 healthy controls (8 males and 6 females, 27-45 years old).