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目的 :了解消化性溃疡出血患者血小板活性及血管内皮细胞功能的变化。方法 :采用酶联免疫吸附双抗体夹心法测定消化性溃疡出血患者血浆 α-颗粒膜蛋白 (GMP- 140 ) ,血管性假血友病因子 (v WF)并与正常对照组作比较。结果 :消化性溃疡出血组患者 GMP- 140及 v WF均明显高于正常对照组 (P<0 .0 1)。结论 :消化性溃疡出血患者血小板活性及血管内皮细胞功能较正常人增强
Objective: To understand the changes of platelet activity and endothelial cell function in patients with peptic ulcer bleeding. Methods: Plasma alpha-granule membrane protein (GMP-140) and von Willebrand factor (vWF) in patients with peptic ulcer bleeding were measured by enzyme linked immunosorbent assay (ELISA) and compared with the normal control group. Results: The levels of GMP-140 and vWF in patients with peptic ulcer bleeding were significantly higher than those in the control group (P <0.01). Conclusion: The platelet activity and the function of vascular endothelial cells in patients with peptic ulcer bleeding are more enhanced than those in normal people