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ＬＡＤＡ为１型糖尿病的一种亚型［１］。胰岛特异性自身反应性Ｔ淋巴细胞在１型糖尿病发病中起着重要的作用。研究表明，胰岛素是一种重要的胰岛自身抗原。本研究观察比较了ＬＡ－ＤＡ、ＩＤＤＭ、典型ＮＩＤＤＭ患者以及正常对照者外周血单个核细胞（ＰＢＭＣ）对胰岛素的增
LADA is a subtype of type 1 diabetes [1]. Islet-specific autoreactive T lymphocytes play an important role in the pathogenesis of type 1 diabetes. Studies have shown that insulin is an important islet autoantigen. This study compared the LA-DA, IDDM, typical NIDDM patients and normal control of peripheral blood mononuclear cells (PBMC) increased insulin