自乙胺碘呋酮(amiodarone)用于治疗复发性室性心律失常以来,已报告本药引起肺毒性者数例。乙胺碘呋酮肺毒性是一种与剂量有关的现象。作者于过去两年使用乙胺碘呋酮治疗47例,发现有肺毒性表现者2例,其中1例报告如下。患者男性,63岁,1981年1月始用乙胺碘呋酮400mg/d治疗对多种抗心律失常药物无效的顽固性室性心动过速。至1982年7月因腹痛入另一间医院,入院时X线检查发现右肺尖有浸润灶,同年4月胸片正常,经支气管肺活检报告正常。1982年9月因体重减轻、衰竭、疲乏、干咳再气促再入院,X线检查发现 Since amiodarone has been used in the treatment of recurrent ventricular arrhythmias, several cases of this drug have been reported to cause pulmonary toxicity. Amiodarone Pulmonary toxicity is a dose-related phenomenon. In the past two years, 47 patients were treated with amiodarone, and 2 patients were found to have pulmonary toxicity. One of them was reported as follows. Patients Male, 63 years old, beginning January 1981 with amiodarone 400mg / d treatment of a variety of antiarrhythmic drugs refractory ventricular tachycardia. To July 1982 due to abdominal pain into another hospital, admitted to the X-ray examination found that the right apex has infiltration stove, chest X-ray normal in April the same year, the bronchopulmonary biopsy reported normal. September 1982 due to weight loss, failure, fatigue, dry cough and then promote gas re-admission, X-ray examination found