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目的探讨骨肿瘤术后复发的原因，复发后肿瘤细胞增殖转移能力的变化及其诊断和治疗。方法分析１７例患者的临床资料，选择其中８例的１６个标本应用免疫组织化学方法测定ＰＣＮＡ、ｎｍ２３蛋白的表达。结果恶性肿瘤１４例，良性肿瘤３例。２例良性肿瘤复发前后ＰＣＮＡ、ｎｍ２３阳性率无变化；６例恶性肿瘤中，４例ＰＣＮＡ阳性率较原发升高，４例ｎｍ２３阳性率较原发降低。结论骨肿瘤术后复发与手术操作密切相关，复发后良性肿瘤保持其原发的特性；而恶性肿瘤复发后其增殖、转移能力有较原发增强的变化趋势。
Objective To investigate the causes of recurrence of bone tumors, the changes of tumor cell proliferation and metastasis after recurrence, and their diagnosis and treatment. Methods The clinical data of 17 patients were analyzed. 16 specimens from 8 of them were selected to measure the expression of PCNA and nm23 protein by immunohistochemistry. Results There were 14 malignant tumors and 3 benign tumors. The positive rate of PCNA and nm23 did not change before and after benign tumor recurrence in 2 cases. In 6 cases of malignant tumors, the positive rate of PCNA increased in 4 cases compared with the original, and the positive rate of nm23 in 4 cases was lower than that in the primary. Conclusions The recurrence of bone tumors is closely related to the operation procedure. After the recurrence, the benign tumor maintains its original characteristics. After the recurrence of malignant tumors, the proliferation and metastasis ability of the tumors have a stronger tendency than the original ones.