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目的：观察食管癌在低氧放疗中的放疗副作用和近、远期效果。方法：食管癌患者７２ 例，以配对原则随机分为低氧组和单照组，用６ ０ Ｃｏ γ线照射，低氧放疗方法为吸入１０ ．５ ％ 的低氧混合气２ 分钟后开始放疗，５ 分钟内完成治疗。结果：放疗后体重增加低氧组为２ ．３ｋｇ ，单照组０ ．１９ｋｇ（ Ｐ＜ ０ ．０５） 。治疗后６ 个月、１ 年、３ 年、５ 年生存率低氧组是８６ ％ 、５６ ％ 、３３ ％ 、１１ ％ ，单照组是６９ ％ 、５０ ％ 、２５ ％ 、５ ．５ ％ （ Ｐ＞ ０ ．０５） 。死亡３２ 例，死因为低氧组局部复发１４ 例，远处转移８ 例，局部复发＋ 远处转移者８ 例，其它２ 例；单照组分别为：１６ 例，１０ 例，８ 例，０ 例（ Ｐ＞ ０ ．０５） 。结论：低氧放疗能够有效地减轻食管癌放疗中副作用，对食管癌放疗后远期疗效没有影响。
Objective: To observe the radiotherapy side effects and short- and long-term effects of esophageal cancer in hypoxia radiotherapy. Methods: Seventy-two patients with esophageal cancer were randomly divided into hypoxia group and single-illumination group according to the pairing principle. They were irradiated with 60 Co γ-rays and inhaled by hypoxia radiotherapy. 5 % of the hypoxic mixture started radiotherapy 2 minutes later and completed treatment within 5 minutes. RESULTS: The weight gain after hypothermia in the hypoxic group was 2. 3kg, single shot group 0. 19kg (P<0.05). After 6 months, 1 year, 3 years and 5 years, the survival rate in the hypoxic group was 86%, 56%, 33%, 11%, while the single phototherapy group was 69%, 50%, 25%, 5. 5 % (P> 0 .05). Thirty-two patients died because of local recurrence in 14 cases of hypoxia, 8 cases of distant metastases, 8 cases of local recurrence + distant metastases, and 2 cases of other cases; 16 cases, 10 cases, 8 cases, 0 Example (P> 0 .05). Conclusion: Hypoxia radiotherapy can effectively reduce the side effects of esophageal cancer radiotherapy, and has no effect on the long-term efficacy of esophageal cancer after radiotherapy.