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lgA 肾病通常认为是良性过程,然而高血压及进行性慢性肾衰并不像以前认为的那样少见,既往报道IgA 肾病病情进展的因素包括:男性;病程长;大量蛋白尿;高血压及肾小球硬化。患者常于上呼吸道感染后蛋白尿及血尿增加。本文旨在研究:①IgA 肾病咽部含漱液中 IgA、分泌型 IgA(S-IgA)和游离分泌成分(FSC);②阐明 C_5,C_9、S-蛋白是否作为 IgA 肾病恶化因素。研究对象为33例 IgA 肾病患者,16例其它肾小球疾病患者及17名正常成人(在2个月内未发生扁桃体炎或咽炎).收集咽部含漱液测定 IgA、S-IgA 和FSC.肾活检作 IgA、IgG、IgM、C_(1q),C_4、C_3、
lgA nephropathy is usually considered a benign process, however, hypertension and progressive chronic renal failure are not as rare as previously thought. Previous reports of IgA nephropathy include: men; long duration; massive proteinuria; hypertension and renal failure Ball sclerosis. Patients often after upper respiratory tract infection proteinuria and hematuria increased. The aim of this paper is to investigate: (1) IgA, secreted IgA (S-IgA) and free-secreted fraction (FSC) in IgA nephropathy pharyngeal gargle; Thirty-three patients with IgA nephropathy, 16 patients with other glomerular diseases and 17 normal adults (tonsillitis or pharyngitis did not occur within 2 months) were collected for pharyngeal gargle, IgA, S-IgA and FSC Renal biopsy was performed for IgA, IgG, IgM, C_ (1q), C_4, C_3,