慢性淋巴细胞白血病(CLL)是一种淋巴细胞肿瘤,绝大多数为单克隆小B淋巴细胞。典型的肿瘤细胞小而圆,形态一致,通常表达CD5、CD19与CD23,存在于外周血、骨髓和淋巴结中,可混有少量幼淋细胞。95%以上的CLL源自B淋巴细胞(B-CLL),T-CLL不足5%。在西方国家,CLL的年发病率约为3/10万, Chronic lymphocytic leukemia (CLL) is a lymphocytic tumor, the vast majority of small monoclonal B lymphocytes. Typical tumor cells are small and round, consistent in morphology, usually expressing CD5, CD19 and CD23, present in peripheral blood, bone marrow and lymph nodes, may be mixed with a small amount of young lymphocytes. Over 95% of CLLs are derived from B lymphocytes (B-CLLs) and less than 5% of T-CLLs. In Western countries, the annual incidence of CLL is about 3 / 100,000,