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目的探讨子宫颈上皮内瘤样病变(cervical intraep ithelial neoplasia,CIN)患者行宫颈环切术(1oop electrical excision procedure,Leep),切割深度对妊娠是否会产生影响。方法 2004年2月至2010年10月在我院确诊的子宫颈上皮内瘤样病变CINⅡ～Ⅲ级并行宫颈环切术的未孕者76例,其中切割深度大于等于15mm者31例,为试验组;切割深度小于15mm者45例,作为对照组。术后对两组患者进行随访,检测受孕时间及不良妊娠结果。结果试验组平均随访44.8个月,随访期间共观察到非意愿性不孕6例;对照组平均随访43.9个月,随访期间共观察到非意愿性不孕7例。两组患者不孕发生风险比较差别无统计学意义(HR=0.89,P=0.68)。试验组随访期间发生不良妊娠事件6例,发生率为19.4%;对照组随访期间发生不良妊娠事件2例,发生率为4.4%。两组比较,试验组显著高于对照组(χ2=4.33,P=0.037),具有统计学意义。结论 CIN患者不良妊娠发生率和宫颈环切术切割深度存在相关性。
Objective To investigate the effect of 1oop electrical excision procedure (Leep) on the pregnancy rate in patients with cervical intraepithelial neoplasia (CIN). Methods From February 2004 to October 2010 in our hospital diagnosed cervical intraepithelial neoplasia CIN Ⅱ ~ Ⅲ parallel cervical circumcision non-pregnant patients 76 cases, of which depth of cut greater than or equal to 15mm in 31 cases, for the test Group; the depth of cut less than 15mm in 45 cases, as a control group. Postoperative follow-up of two groups of patients, detection of pregnancy time and adverse pregnancy outcomes. Results The experimental group was followed up for an average of 44.8 months. Six cases of involuntary infertility were observed during the follow-up period. The control group was followed up for an average of 43.9 months. Seven cases of involuntary infertility were observed during the follow-up period. Two groups of patients with infertility risk difference was not statistically significant (HR = 0.89, P = 0.68). During the follow-up of the experimental group, 6 cases of adverse pregnancy occurred, the incidence rate was 19.4%. In the control group, 2 cases of adverse pregnancy occurred during follow-up, the incidence was 4.4%. The two groups, the experimental group was significantly higher than the control group (χ2 = 4.33, P = 0.037), with statistical significance. Conclusion There is a correlation between the incidence of adverse pregnancy and the depth of cervical circumcision in patients with CIN.