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目的:观察血栓通注射液(XST)对麻醉犬脑循环的影响。方法:杂种犬24条,随机分为对照组、血栓通注射液低、中、高剂量组,单次左侧股静脉滴注给药(匀速滴注15 min)观察收缩压(SAP)、舒张压(DAP)、平均动脉血压(MAP)、心率(HR)、脑血流量(CBF)、脑血管阻力(CVR)和颈内动脉流量等指标的变化。结果:血栓通注射液10、20 mg·kg~(-1)在静脉滴注给药后10～30 min均能明显增加脑血流量和颈内动脉流量,降低脑血管阻力(P<0.05)。各剂量组对血压、心率影响均不明显(P>0.05)。结论:血栓通注射液能明显增加脑血流量和颈内动脉流量,降低脑血管阻力,具有改善麻醉犬脑循环的作用。
Objective: To observe the effect of Xueshuantong Injection (XST) on cerebral circulation in anesthetized dogs. Methods: Twenty-four hybrid dogs were randomly divided into control group, Xueshuantong injection low, medium and high dose group, single left femoral vein infusion (uniform infusion 15 min) observed systolic pressure (SAP) DAP, MAP, HR, CBF, CVR and ICA were measured. Results: Xueshuantong injection 10,20 mg · kg -1 could significantly increase cerebral blood flow and internal carotid artery flow and decrease cerebral vascular resistance 10 ~ 30 min after intravenous infusion (P <0.05) . Each dose group had no significant effect on blood pressure and heart rate (P> 0.05). Conclusion: Xueshuantong injection can significantly increase cerebral blood flow and internal carotid artery flow, reduce cerebral vascular resistance, and improve cerebral circulation in anesthetized dogs.