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目的评价国产吉西他滨联合顺铂治疗非小细胞肺癌术后的疗效和不良反应。方法回顾性分析2006年1月至2008年12月我院收治的126例非小细胞肺癌手术患者的化疗方案,吉西他滨800 mg/m2静脉滴注,第1,8天;长春瑞滨20 mg/m2静脉滴注,第1,8天,分别联合顺铂20 mg/m2第1～3天静脉滴注,21 d为1周期,所有患者均接受至少3个周期治疗;76例采用GP方案组(采用吉西他滨联合顺铂治疗),50例采用NP方案组(采用长春瑞滨联合顺铂治疗);术后6月后行胸部CT和腹部B超检查,观察肿瘤有无复发,比较两组的有效率及毒副反应。结果 GP组术后半年的有效率略高于NP组,两组的主要毒副反应均为骨髓抑制和胃肠道反应,两组血小板减少,白细胞减少,贫血,肝肾功能损害,恶心呕吐的发生率比较,无显著差异。结论国产吉西他滨联合顺铂治疗肺癌术后辅助治疗近期疗效较好,毒副反应小。
Objective To evaluate the efficacy and adverse reactions of domestic gemcitabine and cisplatin in the treatment of non-small cell lung cancer. Methods A total of 126 NSCLC patients admitted to our hospital from January 2006 to December 2008 were retrospectively analyzed. The chemotherapy regimen of gemcitabine 800 mg / m 2 was given on day 1,8 and vinorelbine 20 mg / m2 on day 1, day 8, respectively, combined with cisplatin 20 mg / m2 intravenous drip 1 to 3, 21 d for 1 cycle, all patients received at least 3 cycles of treatment; 76 patients with GP regimen (Using gemcitabine combined with cisplatin treatment), 50 patients with NP regimen (using vinorelbine combined with cisplatin treatment); 6 months after the operation of chest CT and abdominal B-ultrasound, to observe the tumor recurrence compared with the two groups Efficient and toxic side effects. Results The effective rate of six months postoperatively in GP group was slightly higher than that in NP group. The main adverse reactions of both groups were myelosuppression and gastrointestinal reaction. The thrombocytopenia, leukopenia, anemia, liver and kidney dysfunction, nausea and vomiting The incidence was no significant difference. Conclusion Domestic gemcitabine combined with cisplatin in the treatment of postoperative adjuvant therapy of lung cancer has better curative effect and less toxic side effects.