目的:评价气相二氧化硅AEROPERL300 Pharma应用于固化广藿香油的特性。方法:采用AEROPERL300 Pharma固化广藿香油,考察固化粉体的外观形态、流动性、压缩成型性及广藿香油中百秋李醇的受热稳定性,并与国内的沉淀法二氧化硅、环糊精包合技术所得的固化粉体进行了比较。结果:AEROPERL300 Pharma载药量大,可吸附1.5倍于它自身重量的液体药物,所得固化粉末流动性、填充性好,优于沉淀法二氧化硅、环糊精包合技术所得的固化粉体,并可在一定程度上提高广藿香油的热稳定性。结论:AEROPERL300 Pharma在固化液态药物方面将有广泛的应用前景,值得进一步研究。 Objective: To evaluate the properties of fumed silica AEROPERL300 Pharma for curing patchouli oil. Methods: AEROPERL300 Pharma was used to cure patchouli oil. The appearance, fluidity, compression formability and the thermal stability of Plectranthrene in Patchouli oil were investigated. Cyclodextrin inclusion technology cured powder were compared. Results: AEROPERL300 Pharma contains a large amount of liquid drug which can adsorb 1.5 times its own weight of liquid medicine. The resulting cured powder has good fluidity and filling property, which is better than that of precipitated silica and cyclodextrin inclusion technology Powder, and to some extent, improve the thermal stability of patchouli oil. Conclusion: AEROPERL300 Pharma will have broad application prospects in curing liquid drugs and deserves further study.