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通过酶联免疫法测定了刺猬体内脂蛋白（ａ）的含量，从中选出一些脂蛋白（ａ）水平较高的刺猬，研究脱唾液酸糖蛋白－多聚赖氨酸－反义载脂蛋白（ａ）ＲＮＡ连接物对刺猬内源性脂蛋白（ａ）的降低作用．结果表明，该连接物可明显降低刺猬体内脂蛋白（ａ）的水平，而脱唾液酸糖蛋白－多聚赖氨酸－正义载脂蛋白（ａ）ＲＮＡ连接物对刺猬体内脂蛋白（ａ）无降低作用，无脱唾液酸糖蛋白靶向的反义载脂蛋白（ａ）ＲＮＡ寡核苷酸对刺猬体内脂蛋白（ａ）的降低作用明显低于有脱唾液酸糖蛋白靶向的连接物．连接物几乎不影响刺猬体内的纤维蛋白溶酶原的活性，连接物对刺猬脂蛋白（ａ）的降低作用至少可持续１６ｈ．
The content of lipoprotein (a) in hedgehog was determined by enzyme-linked immunosorbent assay (ELISA), and some hedgehogs with higher level of lipoprotein (a) were selected to study the effects of asialoglycoprotein-polylysine-antisense apolipoprotein (A) Reduction of endogenous lipoprotein (a) by hedgehog by RNA ligase. The results showed that the conjugate significantly decreased the level of lipoprotein (a) in hedgehogs, while the activity of asialoglycoproteolytic polypeptide No effect of asialoglycoprotein-targeted antisense apolipoprotein (a) RNA oligos on Hedgehog lipoprotein (a) was significantly lower than that of asialoglycoprotein-targeted ligation Things. The conjugate had little effect on plasminogen activity in hedgehogs and the conjugate had a reduced effect on hedgehog lipoprotein (a) for at least 16 h.