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目的:了解近年来住院系统性红斑狼疮(SLE)患者的主要死亡原因,提高对系统性红斑狼疮病死原因的认识,从而指导临床治疗工作,降低病死率。方法:采用SPSS13.0统计软件对2002年1月～2010年4月哈尔滨医科大学附属第二医院住院治疗并无效死亡的系统性红斑狼疮患者进行回顾性分析。结果:住院患者333例,死亡55例,其中男性4例,女性51例,男女之比为1:12.75;55例死亡患者中,50例为SLE引起的多个脏器损害,占90.91%;受累脏器以肾脏最多见,为45例,衰竭脏器以心脏最多见,其次是肾脏和呼吸系统功能衰竭;SLEDAI评分最低为5分,最高为44分,均为SLE病情活动,并有45例为SLE重度活动,占81.82%。结论:本组病例中,SLE发病第1年内死亡的比例最高,占41.82%。以SLE导致多器官功能障碍为主要死因。早期诊断,及早保护重要脏器功能,控制狼疮活动,预防感染,确保治疗的依从性,是改善SLE预后,提高生存率的关键。
Objective: To understand the main causes of death in hospitalized patients with systemic lupus erythematosus (SLE) in recent years and to improve their understanding of the causes of systemic lupus erythematosus (SLE), so as to guide the clinical treatment and reduce the mortality rate. Methods: SPSS13.0 statistical software was used to retrospectively analyze the patients with systemic lupus erythematosus who were hospitalized and died in the Second Affiliated Hospital of Harbin Medical University from January 2002 to April 2010. Results: There were 333 inpatients and 55 deaths, including 4 males and 51 females. The ratio of male to female was 1: 12.75. Of the 55 deaths, 50 showed multiple organ damage caused by SLE, accounting for 90.91%. The most common kidney disease in 45 cases, the most common heart failure in the exhausted organs, followed by the kidneys and respiratory failure; the lowest SLEDAI score of 5 points, the highest of 44 points, were SLE disease activity, and 45 Cases for SLE severe activity, accounting for 81.82%. Conclusion: In this group of patients, the proportion of death in the first year of SLE was the highest (41.82%). To SLE lead to multiple organ dysfunction as the main cause of death. Early diagnosis, early protection of important organ function, control of lupus activity, prevention of infection, to ensure compliance with treatment is to improve the prognosis of SLE and improve the survival rate of the key.