AIM:To explore the hypothesis that the combined treatment with higenamine(HG)and[6]-gingerol([6]-GR)protects against doxorubicine(DOX)-induced cardiotoxicity at least partly through anti-apoptotic mechanisms exerted on cardiomyocytes.METHODS:All experiments were performed on neonatal rat cardiomyocytes(NRCs).Cell viability was measured by an MTT viabili- To explore the hypothesis that the combined treatment with higenamine (HG) and [6] -gingerol ([6] -GR) protects against doxorubicine (DOX) -induced cardiotoxicity at least partially through anti-apoptotic mechanisms exerted on cardiomyocytes. METHODS : All experiments were performed on neonatal rat cardiomyocytes (NRCs). Cell viability was measured by an MTT viabili-