活性氧作为新的信号因子 ,在基因复制、转录、翻译中起着重要作用 ,肿瘤的发生与活性氧密切相关 ,含锰超氧化物歧化酶 (MnSOD)作为最重要的抗氧化酶在机体的防御系统中发挥着重要作用。MnSOD活性在肿瘤组织内显著降低甚至检测不到及MnSOD基因转染的肿瘤细胞表型逆转的实验提示 ,MnSOD作为一种新型的肿瘤抑制因子 ,很可能为肿瘤问题的解决提供一条新的思路。 As a new signal factor, active oxygen plays an important role in gene replication, transcription, and translation. The occurrence of tumor is closely related to reactive oxygen species. Manganese superoxide dismutase (MnSOD) is the most important antioxidant enzyme in the body. Defense systems play an important role. The MnSOD activity was significantly reduced or even undetectable in the tumor tissue and the phenotypic reversal of the MnSOD gene transfected tumor cells suggested that MnSOD as a novel tumor suppressor may provide a new idea for the solution of tumor problems.