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目的探讨大剂量红霉素治疗早产儿喂养不耐受的疗效。方法选取2013年1月—2014年1月于贵港市妇幼保健院就诊的喂养不耐受早产儿54例,随机分为观察组与对照组,各27例。对照组予以常规治疗,观察组在对照组基础上加用大剂量红霉素治疗。观察两组肠内热卡达标(即达到50kcal·kg-1·d-1)时间、住院时间、全胃肠外营养(TPN)时间及并发症发生情况。结果观察组肠内热卡达标时间、住院时间及TPN时间短于对照组,差异均有统计学意义(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论大剂量红霉素治疗早产儿喂养不耐受的疗效显著,能改善早产儿胃肠动力,缩短住院时间,且并发症少。
Objective To investigate the effect of high-dose erythromycin on feeding intolerance in premature infants. Methods From January 2013 to January 2014, 54 infants who were intolerant to premature infants in Guigang MCH hospital were randomly divided into observation group and control group, with 27 cases in each group. The control group was given routine treatment. The observation group was treated with high-dose erythromycin on the basis of the control group. The enteral heat-card compliance (50kcal · kg-1 · d-1), hospital stay, total parenteral nutrition (TPN) time and complications were observed. Results The time of enteral heat card admission, duration of hospitalization and TPN time were shorter in the observation group than in the control group (P <0.05). There was no significant difference in the complication rates between the two groups (P> 0.05). Conclusion The high dose of erythromycin in treating premature infants has significant effect on feeding intolerance, which can improve the gastrointestinal motility in premature infants and shorten the hospital stay with less complications.