一、概述非甾体消炎镇痛药在近十余年来有较大的进展,国内外均有一些评述。非甾体消炎镇痛药之所以受到重视,主要是由于一般肾上腺皮质激素虽能有效地控制炎症的发展和消除炎症而造成的功能障碍,但存在一些不良反应。特别是使用不当时,有促使感染易于扩散,创口不易愈合,对某些慢性炎症长期使用后,可出现类似肾上腺皮质功能亢进综合症,造成肾上腺皮质萎缩以及机能不全等不良反应。非甾体消炎镇痛药,因非甾体结构,而且其消炎机制一般并非在体内刺激肾上腺皮质,促使分泌皮质激素而达到消炎目的。因此,非甾体消炎药在治疗上可以克服皮质甾体激素消炎作用而产生的许多不良反应。 First, an overview of non-steroidal anti-inflammatory analgesics in the past ten years have made great progress, both at home and abroad have some comments. The reason why non-steroidal anti-inflammatory analgesics have been taken seriously is that the general adrenal cortex hormones can effectively control the development of inflammation and eliminate the dysfunction caused by inflammation, but there are some adverse reactions. In particular, improper use, there is to promote the spread of infection is easy to wound healing is not easy, for some chronic inflammation after long-term use, there may be similar adrenal insufficiency syndrome, resulting in adrenal cortex atrophy and hypoplasia and other adverse reactions. Non-steroidal anti-inflammatory analgesics, due to non-steroidal structure, and its anti-inflammatory mechanism is not generally stimulate the adrenal cortex in the body, prompting the secretion of corticosteroids to achieve the purpose of anti-inflammatory. Therefore, non-steroidal anti-inflammatory drugs in the treatment of corticosteroids can overcome the anti-inflammatory effect of many adverse reactions.