论文部分内容阅读
目的 :观察抗血管紧张素Ⅱ 1型 (AT1)受体和α1肾上腺素受体自身抗体的产生是否由高血压脑卒中所引起。方法 :以合成的AT1受体、α1肾上腺素受体细胞外第二带多肽片段作为抗原 ,用ELISA法检测高血压脑卒中患者及正常人 (各 2 81例 )血清中的抗AT1和α1受体自身抗体。结果 :2 81例高血压脑卒中患者中 12 8例抗AT1受体自身抗体阳性 (阳性率 4 5 .6 % ) ,97例抗α1受体自身抗体阳性 (阳性率 34.5 % ) ,两种抗体阳性均明显高于正常血压对照者 (分别为 9.3%、6 .8% ,P <0 .0 1) ,但在 3种类型脑卒中亚组中 ,抗AT1和α1受体自身抗体阳性率无明显差异 (P >0 .0 5 ) ,按脑卒中发病时间分亚组 ,抗体阳性率也无明显差异。结论 :高血压脑卒中患者抗AT1和α1受体自身抗体检出频率显著增高 ,该抗体并非继发于脑卒中 ,而是与原发性高血压本身有关
Objective: To observe whether the production of autoantibodies to anti-angiotensin Ⅱ 1 (AT1) and α1-adrenoceptors is caused by hypertensive stroke. Methods: The anti-AT1 and α1 receptors in sera of hypertensive stroke patients and normal subjects (2 81 cases each) were detected by ELISA with synthetic AT1 receptor and α1 adrenoceptor extracellular second polypeptide fragment as antigen Body autoantibodies. Results: Of the 81 patients with hypertension stroke, 128 were anti-AT1 receptor autoantibodies (positive rate was 45.6%), 97 were anti-alpha1 receptor autoantibodies (34.5%), two antibodies (9.3% vs.6.8%, P <0.01). However, the positive rates of anti-AT1 and α1 receptor autoantibodies in the three subgroups of stroke were Significant difference (P> 0.05), according to the time of stroke sub-subgroup, the antibody positive rate was no significant difference. Conclusion: The detection frequency of anti-AT1 and α1 receptor autoantibodies in hypertensive stroke patients was significantly higher than that of secondary stroke, but not secondary to essential hypertension