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为了研究大脑皮层体感Ⅰ区与痛觉以及针刺镇痛作用的关系,以钾离子透入下肢皮肤作为痛刺激,以操作式条件反射作为痛指标,用钨丝微电极记录顶叶皮层体感Ⅰ区单个神经元的电活动,对10只清醒、可以活动的猴子进行了实验观察。在下肢的皮层代表区分离和记录了能对各种传入刺激起反应的神经元215个。有28个神经元可以对皮肤伤害性刺激起反应,其中有25个神经元出现兴奋反应(兴奋型神经元),3个神经元出现抑制反应(抑制型神经元)。对12个伤害性神经元进行了针刺效应的观察。在针刺过程中有6个神经元(4个兴奋型,2个抑制型)对伤害性刺激的反应受到抑制。其中有些神经元的抑制可伴有痛阈的升高,但两者并未呈现严格的平行关系。皮层体感Ⅰ区中亦可记录到会聚性神经元,即同一神经元既可接受皮肤机械刺激,亦可接受皮肤伤害性刺激。这种神经元可以对不同感觉类型的刺激出现不同型式的反应。在针刺时,往往只有伤害性刺激引起的反应受到抑制,而机械刺激引起的反应没有明显变化。以上实验表明,皮层体感Ⅰ区内存在着可以接受皮肤伤害性刺激的神经元。针刺可以使某些神经元对伤害性刺激的反应减弱。但是这种效应可能不是发生在皮层本身,而是续发于皮层下结构活动的变化。
In order to study the relationship between the sensory area I and the pain sensation and acupuncture analgesia in the cerebral cortex, potassium ion penetrated the skin of the lower extremity as a pain stimulus and the operative conditioned reflex as a pain index. Electrical activity of individual neurons, experimental observation of 10 awake, movable monkeys. 215 neurons that responded to various afferent stimuli were isolated and recorded in the cortical representation of the lower limbs. Twenty-eight neurons respond to skin noxious stimulation, of which 25 are excited (excited neurons) and 3 are neuronal inhibitory (inhibitory neurons). Twelve nociceptive neurons were observed for acupuncture effects. In the acupuncture process, there are 6 neurons (4 excited, 2 inhibitory) to nociceptive response was inhibited. Some of these neuronal suppression may be accompanied by increased pain threshold, but the two did not show a strict parallel relationship. Cortical somatosensory I area can also be recorded in the convergence of neurons, that the same neurons can accept both mechanical stimulation of the skin can also accept skin noxious stimulation. This neuron can respond differently to different types of sensations. In acupuncture, often only nociceptive response was inhibited, and mechanical stimulation caused no significant change in response. The above experiments show that there is a layer of skin sensory cortex in skin irritation can accept the neurons. Acupuncture can make some neurons to nociceptive response weakened. However, this effect may not occur in the cortex itself, but the changes in the activities of the subcutaneous structure.