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为了探讨乙型肝炎病毒宫内感染的相关因素。对１２５例ＨＢｓＡｇ阳性孕妇及其婴儿进行了随访调查。按０、１、６方案对婴儿接种乙型肝炎疫苗，婴儿出生后２４小时内接种第一针疫苗时，同时注射乙型肝炎高效价免疫球蛋白。用酶联免疫吸附法检测孕妇及婴儿的ＨＢＶ感染指标。结果，共检出１３例婴儿血清中ＨＢｓＡｇ阳性，其中８例出生时即为阳性，５例为随访时阳转。宫内感染的发生率为１０．４％（１３／１２５）。单因素分析和ｌｏｇｉｓｔｉｃ多元回归分析表明，母亲ＨＢｅＡｇ阳性、先兆早产与宫内感染的发生有关。结论：母亲ＨＢｅＡｇ阳性、先兆早产是宫内感染的相关因素，其ＲＲ值分别为３１．２７和１０．８７。
In order to explore the related factors of hepatitis B virus intrauterine infection. A total of 125 HBsAg positive pregnant women and their infants were followed up. According to 0,1,6 programs vaccinated infants hepatitis B vaccine, the first vaccination within 24 hours after the baby was vaccinated at the same time injected with hepatitis B high titer immunoglobulin. Enzyme linked immunosorbent assay for HBV infection in pregnant women and infants. As a result, HBsAg was positive in 13 infants, of which 8 were positive at birth and 5 were positive at follow-up. The incidence of intrauterine infection was 10.4% (13/125). Univariate analysis and logistic multiple regression analysis showed that maternal HBeAg-positive, threatened preterm birth was associated with the occurrence of intrauterine infection. Conclusion: The mothers with HBeAg-positive and threatened preterm birth are the related factors of intrauterine infection with RRs of 31.27 and 10.87, respectively.