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SL E是抗 sm等自身抗体为特征的多系统受累的自身免疫性疾病。IL- 2是 T淋巴细胞亚群产生 ,在 SL E患者血清中均有升高 ,则判断 SL E活动期敏感的指标。IL- 6具有多功能细胞因子 ,它的分泌异常促使体内大量自身抗体产生 ,从而导致机体的免疫损伤。r-干扰素是干细胞和 NK细胞分泌的一种细胞因子 ,在活动期 SL E血清中增高。总之 ,细胞因子在 SL E发病过程中起重要作用 ,所以各种细胞因子的研究、检测和临床治疗 ,对于 SL E的诊断、预后都有重要意义。
SL E is a multisystem autoimmune disease characterized by anti-sm and other autoantibodies. IL-2 is a subset of T-lymphocytes that is elevated in the sera of patients with SLE, and is a sensitive indicator of SL E activity. IL-6 has a multi-functional cytokine, abnormal secretion of which prompted a large number of autoantibodies in vivo, resulting in the body’s immune damage. r-Interferon is a cytokine secreted by stem cells and NK cells and is elevated in active SLE sera. In short, cytokines play an important role in the pathogenesis of SL E, so the research, detection and clinical treatment of various cytokines are of great significance for the diagnosis and prognosis of SL E.